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POLYAH - Recognition of 3'-end cleavage and polyadenilation region of human mRNA precursorsMethod description:Algorithm predicts potential position of poly-A region by linear discriminant functions combining characteristics describing various contextual features of these sites. The default LDF threshold in the server is equal 0. Accuracy:The accuracy has been estimated for the set of 131 poly-A regions and 1466 non-poly-A regions of human genes, having AATAAA sequence. For 86% accuracy poly-A region prediction the algorithm has 8% false predictions (Sp=50%; C=0.62). For example, with threshold 0.7 it predicts 8 of 9 poly-A sites of AD2 genome (35937 bp.) and overpredict 4 false (Compare with method of poly-A site prediction (CABIOS 1994,10,597-603), which for 8 true predicted sites gives 968 false positive sites). POLYAH output:
For example:HSG11C4A 1741 bp DNA PRI 21-FEB Length of sequence- 1741 1 potential polyA site was predicted Pos.: 988 LDF- 4.06 |
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